We found that 1) microarray analysis detected increased TRIM72 expression in airway epithelial cells from patients with severe asthma [42]; 2) ATII cells from surfactant protein C (Sftpc)-deficient mice had increased TRIM72 expression [43]; 3) H5N1 viral infection increased TRIM72 expression in human airway epithelial Calu-3 cells (NCBI GEO dataset GSE43204); 4) expression of Trim72 mRNA was upregulated in ATI and ATII cells from IPF lung through single-cell RNA-seq analysis (https://www.biorxiv.org/content/10.1101/759902v1). Here, SFTPC is linked to asthma.