TRIM72 and pulmonary fibrosis: Through in vivo characterization of transgenic mouse lines of T72KO and T72OE, we found that ablation of TRIM72 reduces overall alveolar epithelial integrity, histological destruction, and barrier function of the lung following bleo injury while aggravates injury-induced inflammatory cell infiltration and lung fibrosis as compared to WT controls (Figs. 7, 8 and 9).