These models are as follows: GM-CSF-driven (i.a. mBSA day 0, subcutaneous (s.c.)GM-CSF days 0–2, [5]), TNF-driven (i.a. mBSA day 0, s.c. TNF days 0–2, [9]), and CCL17-driven (i.a. mBSA day 0, s.c. CCL17 days 0–2, [8]) arthritis. This evidence concerns the gene CSF2 and arthritic joint disease.