IL23A and bacterial infectious disease: The mBSA “priming” stage may contribute to subsequent cytokine effects, as suggested, for example, by our data in Additional file 1: Figure S2, wherein reduced tissue macrophage number might contribute to the lower tissue inflammatory response noted in Il23p19−/− mice and which in turn could be due to their reduced number of steady-state blood monocytes, as shown before in a bacterial infection model [60].