PRSS23 and breast cancer: Our data thus suggest that KMT2C may be important for regulation of estrogen signaling in CRC tumorigenesis, but unlike previous reports in breast cancer [49], we saw minor effects of PRSS23 knockdown on CRC cell proliferation, suggesting the possibility that other KMT2C regulated genes are more important for promotion of CRC tumorigenesis following loss of KMT2C.