FOXA1 and colorectal carcinoma: Although KMT2C is known to interact with certain sequence specific transcription factors, such as FOXA1 [41], based on our observations, its monomethylase activity is not highly targeted at specific genes as deposition of H3K4me1 in CRC cells where KMT2C is restored is found globally at enhancer regions, not at a specific sub-set of enhancers.