The results of overall population reject any association between MMP-3 gene − 1612 5A/6A SNP and risk of MS across all genotype models including; dominant model (OR = 1.18, 95% CI = 0.66–2.13, P = 0.57), recessive model (OR = 0.57, 95% CI = 0.18–1.79, P = 0.33), allelic model (OR = 1.11, 95% CI = 0.88–1.41, P = 0.39), 6A6A vs. 5A5A model (OR = 1.15, 95% CI = 0.62–2.11, P = 0.66), and 5A6A vs. 5A5A model (OR = 1.24, 95% CI = 0.64–2.39, P = 0.52). Here, MMP3 is linked to myeloid sarcoma.