To date, several surveys have been conducted addressing the possible association between polymorphisms of the MMP gene family, including MMP-91562 C/T (rs3918242), MMP-3 (− 1612 5A/6A), and MMP-2 (− 1306 C/T) and risk of MS, resulting in inconsistent and inconclusive results. This evidence concerns the gene MMP3 and myeloid sarcoma.