As noted in recent studies, several genes, including interleukin (IL) 6, IL-12, vitamin D receptor (VDR), Signal transducer and activator of transcription (STAT) 4, Protein tyrosine phosphatase, non-receptor type 22 (PTPN22), CD40, programmed cell death (PD1/PD-L1), and Matrix metalloproteinases (MMPs) have been correlated with MS and attracted much attention to investigating more genetic factors contributing to MS risk [10–17]. The gene discussed is CD40; the disease is myeloid sarcoma.