On the other hand, M2 polarization is promoted both by Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway and by the anti-inflammatory cytokines Interleukin-4 (IL-4) and Interleukin-10 (IL-10); they perform anti-inflammatory and immunosuppressive effects by releasing anti-inflammatory cytokines (IL-10) and promote tumor progression. Here, IL4 is linked to neoplasm.