Moreover, it has been demonstrated that the cannabinoid CBD inhibits the production of the pro-inflammatory cytokines IL-6, IL-8 and TNF-α in in vitro models of allergic contact dermatitis [75], and in osteoarthritis, THC reduced TNF-α, IL-1β, IL-6 and IL-8 release in LPS-stimulated MG63 cells, demonstrating the anti-inflammatory CB2-mediated role [76]. This evidence concerns the gene TNF and allergic contact dermatitis.