Moreover, PS (ECOG), tumor grade, TLR2 196-to-174 del, TaqI, ApaI and FokI variants emerged as independent factors associated with decreased OS (HR: 3.7, 95% CI: 2.4–5.9, p < 0.001; HR: 1.8, 95% CI: 0.7–5.1, p < 0.001; HR: 2.1, 95% CI: 1.3–3.4, p = 0.003; HR: 1.3, 95% CI: 1.0–1.5, p = 0.029; HR: 1.6, 95% CI: 1.3–2.0, p < 0.001; HR: 1.4, 95% CI: 1.1–1.8, p = 0.005), as shown in Table 5. The gene discussed is TLR2; the disease is neoplasm.