The I-SPY 2 TRIAL (Investigation of Serial Studies to Predict Your Therapeutic Response Through Imaging and Molecular AnaLysis 2, I-SPY 2) was an adaptive randomized phase II study aiming to evaluate various innovative therapeutic compounds in the neoadjuvant setting, in specific subsets of BC defined by combining the expression of HER2 and hormone receptors, with the Mammaprint signature [17,18]. This evidence concerns the gene NR4A1 and breast cancer.