Furthermore, CIGB-300 promoted T-ALL cell apoptosis as measured by Annexin V-APC conjugate and 7-aminoactinomycin D (7-AAD) staining (Figure 1C) and caspase 3 and poly (ADP-ribose) polymerase (PARP) cleavage (Figure 1D). The gene discussed is CASP3; the disease is acute lymphoblastic leukemia.