CASP3 and melanoma: Recent investigations on the mechanisms of action of climacostol demonstrated that it reduces the viability/proliferation of melanoma cells, causing rapidly occurring DNA damage, also inducing the intrinsic apoptotic pathway characterized by the dissipation of the mitochondrial membrane potential, the translocation of Bax to the mitochondria, the release of cytochrome c from the mitochondria, and the activation of caspase 9-dependent cleavage of caspase 3 [29,30].