RB1 and Emery-Dreifuss muscular dystrophy: Interestingly, the authors found that expression of lamin A rod-domain mutants associated with the Emery-Dreifuss muscular dystrophy (EDMD), G232E, Q294P and R386K, considerably increased the expression of RNF123, which was associated with decreased protein levels of lamin B1, LAP2α and pRb.