Interestingly, the authors found that expression of lamin A rod-domain mutants associated with the Emery-Dreifuss muscular dystrophy (EDMD), G232E, Q294P and R386K, considerably increased the expression of RNF123, which was associated with decreased protein levels of lamin B1, LAP2α and pRb. This evidence concerns the gene RNF123 and Emery-Dreifuss muscular dystrophy.