SUMO1 and familial dilated cardiomyopathy: Subsequently, Tesson’s group showed that overexpression of other disease-associated lamin A/C mutants, including DCM-related Q353K and EDMD-related H222P and R386K mutants, also affects the localization of SUMO1 and Ubc9 in transfected mouse myoblast C2C12 cells [84].