In a recent study, 194 circulating inflammatory proteins were analyzed in T1DM and T2DM subjects from three independent cohorts, identifying an extremely robust kidney risk inflammatory signature (KRIS), consisting of 17 proteins of the TNFR superfamily members that were associated with a 10-year risk of ESRD [10]. This evidence concerns the gene TNFRSF1A and type 2 diabetes mellitus.