The CANTATA-SU (NCT00968812) study in T2DM patients treated with metformin and canagliflozin, showed a reduction in TNFR1, IL-6, metalloproteinase-7 and fibronectin-1 levels, suggesting that canagliflozin contributes to reverse molecular processes related to inflammation, extracellular matrix turnover and fibrosis [316]. The gene discussed is TNFRSF1A; the disease is type 2 diabetes mellitus.