Results show that leptin signaling increases the expression of tumor progression and chemoresistance-related genes (ABCB1, WNT4, ADHFE1 [22], TBC1D3 [23], LL22NC03 [24], RDH5, ITGB3 [25]) in TNBC cells (Figure 8A). This evidence concerns the gene WNT4 and neoplasm.