We have previously shown that overexpression of OSM induces ECM accumulation and accumulation of arginase-1+ (Arg1) alternatively activated (AA/M2-like) macrophages, which was associated with eosinophilia and a Th2-like skewed cytokine profile in lungs of C57Bl/6 mice [22]. The gene discussed is ARG1; the disease is Increased total eosinophil count.