NOS2 and atherosclerosis: Among the inflammatory mediators, the eicosanoids derived from the COX-2 and/or mPGES-1-mediated n-6 PUFA arachidonic acid metabolism, such as prostaglandin E2 (PGE2), and thromboxane, and expression of inducible nitric oxide synthase plays a key role in endothelial activation and trans-endothelial migration of monocytes into the vessel wall, two traditional risk factors for atherosclerosis.