In addition, ELK, STAT1, PPARG, YY1, CEBPB, GATA2, SREBF1, and CREB1 were identified as transcription regulators in the blood of MCI and AD and SREBF1 in AD, suggesting there is some conservation in the regulation of peripheral and central gene expression in dementia [13]. Here, YY1 is linked to Alzheimer disease.