Similarly, switch genes identified in VaD are mostly involved in cancer, PI3K-AKT, ubiquitin-mediated proteolysis (Figure 6b, Supplementary Table S5), whereas FTD is associated with cancer, Epstein–Barr virus infection, and ubiquitin-mediated proteolysis (Figure 6c, Supplementary Table S5). Here, AKT1 is linked to frontotemporal dementia.