We observed that CM collected from TGFBR3-overexpressing OC-2 cells decreased migration and invasion of OC-2 cells (Figure 6a) and CAFs isolated from oral cancer specimens (Figures S5 and S20 and Figure 6b), and inhibited tube formation of human umbilical vein ECs (HUVECs) (Figure 6c), without affecting proliferation of CAFs or ECs (Figure S6). Here, TGFBR3 is linked to lip and oral cavity carcinoma.