Through the analysis of three studies [26,27,28], the expression of TGFBR3 mRNA was 3.836-fold lower in oral cancer tissues than that in the normal oral mucosa (p = 1.17 × 10−25), 3.677-fold lower in tongue cancer tissues than that in healthy tongues (p = 3.35 × 10−7), and 2.487-fold lower in HNC tissues than that in the normal buccal mucosa (p = 1.28 × 10−6) (Figure 1a). Here, TGFBR3 is linked to lip and oral cavity carcinoma.