We next investigated whether ARRB2 or GIPC1 plays a role in SMAD4-independent, TGFBR3-mediated migration and invasion of oral cancer cells by knocking down ARRB2 or GIPC1 in TGFBR3-overexpressing CAL-27 cells. This evidence concerns the gene TGFBR3 and lip and oral cavity carcinoma.