The flavonol quercetin, perhaps one of the most studied in the context of obesity, increases adiponectin and downregulates MCP-1, TNF-α, and IL-6 expressions in adipocyte macrophage co-cultures and HFD mice models, via the inhibition of the NF-κB, AP-1, and mitogen-activated protein kinase (MAPK) pathways [110]. The gene discussed is NFKB1; the disease is obesity due to melanocortin 4 receptor deficiency.