SPDL1 and neoplasm: Of note, we found that patients with elevated sPD-L1, above the median value, had a greater metabolic tumor burden, expressed by metabolic tumor volume (MTV, 115.3 vs. 35.5, p = 0.034) and total lesion glycolysis (TLG, 687 vs. 210.1, p = 0.049) (Figure 2).