Various glymphatic studies have suggested that glymphatic dysfunction is responsible for the waste accumulation and may lead to various neurological diseases [132] including beta-amyloid and tau protein accumulation in Alzheimer’s disease, alpha-synuclein protein accumulation in Parkinson’s disease, and huntingtin accumulation in Huntington’s disease. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.