This is consistent with a previous study in which the apoptosis inhibitory action of Citicoline was demonstrated using Annexin V/ FITC Flow cytometry analysis in a mouse model of cerebral malaria (CM); administration of Citicoline rescued cells in an experimental model of CM in vitro as well conferred partial protection against cell death and neurological syndrome in murine CM [17]. The gene discussed is ANXA5; the disease is cerebral malaria.