In this study, the characteristics of several inflammatory factors (IL‐1β, IL‐2 receptor (IL‐2R), IL‐6, IL‐8, IL‐10, TNF‐α, CRP, serum ferritin, and procalcitonin [PCT]) and lymphocyte subsets of 27 patients with severe COVID‐19 patients were examined. The gene discussed is CRP; the disease is COVID-19.