ALPL and hypophosphatasia: Increases in cranial bone density, mineral content and volume fraction by TNAP treatment in BALB/c Crouzon mice is consistent with results showing that recombinant mineral targeted TNAP treatment rescues mineralization of craniofacial and long bones in in the Alpl-/- mouse model of infantile hypophosphatasia (HPP) and humans with infantile and childhood HPP [30, 31, 33, 40].