IL1B and type 2 diabetes mellitus: Interestingly, NFKB1 gene methylation status was correlated only with IL-1β and IL-1Ra levels in T2DM patients: negatively with IL-1Ra levels (r = -0.33, P = 0.049) and positively with IL-1β levels (r = 0.43, P = 0.056) in the plasma of female patients (Fig 3B and 3C).