Multivariate Cox regression model adjusted by age, lymph node metastasis (LNM), T stage and pathological grade also reported that the level of PFKP could serve as an independent prognostic factor for patients with BC (P = 0.001, HR = 2.742, 95% CI 1.505 to 4.994, Fig 5C and S3 Table). Here, PFKP is linked to breast cancer.