Given that we have illustrated that dysfunction of BRCA1 or ZBRK1 led to the overexpression of PFKP and subsequently enhanced aerobic glycolysis and the malignant phenotype of breast cancer, it is worthy to elucidate the underlying mechanism that how BRCA1 exerts its functions in regulating the balance of EMT and rapid aerobic glycolysis to meet different situations. The gene discussed is BRCA1; the disease is breast cancer.