Doing so revealed no differences in CD4+ PBMC production of IL-4 (Kruskal-Wallis, P = 0.3402), IL-17A (Kruskal-Wallis, P = 0.9006), or IFNγ (Kruskal-Wallis, P = 0.0396; Dunn’s MC P > 0.9999) in ccRCC subjects, although tumor-free donors with obesity were found to have decreased production of IFNγ compared to non-obese tumor-free donors (Kruskal-Wallis, P = 0.0396; Dunn’s MC P = 0.0215) (Fig 2A). The gene discussed is IL17A; the disease is obesity due to melanocortin 4 receptor deficiency.