In the cancer subgroups, there was a significant relationship between high LAT1 expression and poor OS in solid tumors observed in patients with lung cancer (HR = 1.573, 95% CI = 1.309–1.890, P < 0.001), non-small cell lung cancer (HR = 1.554, 95% CI = 1.345–1.794, P < 0.001), pancreatic cancer (HR = 2.052, 95% CI = 1.613–2.724, P < 0.001) and biliary tract cancer (HR = 2.253, 95% CI = 1.562–3.227, P < 0.001). Here, SLC7A5 is linked to familial pancreatic carcinoma.