Furthermore, the heterodimeric complex formed by the binding of LAT1 and CD98 plays a significant role in integrin signaling of cancer cells, sequentially activating the phosphatidylinositide 3-kinase/AKT (PI3K/AKT), p130CAS and focal adhesion kinase (FAK) signaling pathway [31, 32]. This evidence concerns the gene PTK2 and cancer.