MTOR and neoplasm: One the other hand, AURKA plays a pivotal role in tumor survival by provoking Bcl-2 and MCL-1 [35, 36], and anti-apoptotic factors levels, blocking Bax, Bim, PUMA apoptotic mediators activity [35, 37, 38], along with disruption of the mammalian Target of Rapamycin (mTOR) autophagy pathway [38].