For example, the node representing the CALU protein in Fig 1, having an out-degree of 12 and an in-degree of 14, indicating the important role of this protein in the complex network existed between known cancer related signaling factors such as AURKA, EEF2K, EGFR, MCM2, RAF1, etc., which mediate the cancer cells proliferation and survival. Here, CALU is linked to cancer.