KREMEN2 and amyotrophic lateral sclerosis: Genes found up-regulated by treatment in the SAMP8 hippocampus included Baiap3, a protein involved in retrograde trafficking [32]; Prph, a gene affected by mutations in Amyotrophic Lateral Sclerosis [33]; Fabp7 [34,35] and Doc2a [36], genes required for cognitive function and memory; Kremen2 and Rspo1, regulators of the WNT pathway [37].