Iadademstat (ORY-1001), a highly potent selective KDM1A inhibitor in development for treatment of oncological diseases [8], reversed cortical synaptic plasticity deficit and the working memory of SETD1 +/- mice, a model for schizophrenia [64].These data provide support for the potential of KDM1A inhibitors in learning and memory. The gene discussed is KDM1A; the disease is schizophrenia.