GAPDH and Alzheimer disease: Moreover, oxidative GAPDH protein, which accumulates in the brains of patients with AD, colocalizes and specifically interacts with the Aβ precursor protein (APP) [15, 16], Aβ (1–42) [17, 18], NFTs [19, 20], and paired helical filament-tau (PHF-tau) [21, 22].