GAPDH and major depressive disorder: However, the blood S-glutathionylated GAPDH levels in the 37 clinical controls aged 70–89 years from the Outpatient Psychosomatic Clinic, who suffered from depression, dementia, insomnia, or high blood pleasure, were higher (230.5 ± 179.3 ng/dL) than those in the 42 healthy controls aged 70–89 years recruited from the community (8.05 ± 20.51 ng/dL) (p < 0.001) (Fig 3).