In addition, studies with Murine Y1 adrenocortical tumor cells have shown that the intracellular level of ARA in mitochondria is controlled by acyl-CoA synthetase long chain family member 4 (ACSL4) and acyl-CoA thioesterase 2 (ACOT2) [28]. This evidence concerns the gene ACOT2 and adrenal cortex neoplasm.