In this study, hub genes, KCNMB1, AGPAT4, SVEP1, ADARB1, DCAF5, NRP1, PDIA6, AHI1, ANO6, VPS26A, DNAJC10, TMEM106B, ETF1, GCC2, FNBP1, and GOLGA8B, which might be used as targets and biomarkers for treating GBM were selected. This evidence concerns the gene GCC2 and glioblastoma.