In this study, hub genes, KCNMB1, AGPAT4, SVEP1, ADARB1, DCAF5, NRP1, PDIA6, AHI1, ANO6, VPS26A, DNAJC10, TMEM106B, ETF1, GCC2, FNBP1, and GOLGA8B, which might be used as targets and biomarkers for treating GBM were selected. The gene discussed is SVEP1; the disease is glioblastoma.