In summary, even though more studies are needed to deeply understand the evaluated mechanisms, these results reinforce the valuable role of mitophagy and innate immune response, along with circadian clock signalling, in viral‐induced FHF, and highlight the modulatory effects of melatonin on these processes, placing the indole as a potential candidate for therapeutic application in human FHF and reinforcing its potential as an antiviral agent. Here, CLOCK is linked to TNF receptor 1-associated periodic fever syndrome.