While in contrast to recent reports that showed reducing PE levels in skeletal muscle by inhibiting key phospholipid synthesis pathways (phosphatidylserine decarboxylase) results in muscle atrophy (Heden et al., 2019; Selathurai et al., 2019), our findings and those by Uchitomi et al. (2019) reveal that age‐induced muscle atrophy may be linked to elevated phospholipids levels in skeletal muscle. Here, PISD is linked to muscle atrophy.