The present study describes upregulation of gene transcription for several fibrosis mediators, including HIF1A, MMP2, MMP7, MMP9, TIMP1, and TGFB1, as well as downregulation of the proangiogenic factor VEGFA, in renal tissues from cats with naturally occurring CKD, when compared to those from healthy control cats. The gene discussed is MMP2; the disease is chronic kidney disease.