It was hypothesized that as in ischemia‐induced experimental CKD, and compared to tissues from healthy control cats, gene transcript levels of HIF1A, MMP2, MMP7, MMP9, TIMP1, and TGFB1 would be increased, and those of VEGFA would be decreased, in renal tissues from cats with naturally occurring CKD. Here, HIF1A is linked to chronic kidney disease.