HIF1A and Myocardial fibrosis: CTRP1, CTRP3, and CTRP9 increase expression of HIF1α and vascular endothelial growth factor, promote secretion of endothelial cell angiogenic factors, inhibit neointimal hyperplasia and VSMC proliferation, and inhibit myocardial fibrosis, thus supporting the survival and regeneration of ischemic cardiomyocytes (Fig. 1).