CTRP3 affects inhibitory toll-like receptors (TLRs) and nuclear factor kappa B (NF-κB) signaling pathways to reduce secretion of inflammatory adipocytokines, thus attenuating both insulin resistance and obesity-related, chronic, systemic anti-inflammatory responses [17, 18]. Here, C1QTNF3 is linked to obesity due to melanocortin 4 receptor deficiency.