LPAR2 and neurodegenerative disease: Since our data show that LPAR2 deficiency prevented age-related hippocampal hyperexcitability, the observed LTP enhancement in LPAR2 knockout mice points to secondary beneficial mechanisms resulting from life-long shielding against periods of glutamatergic "overflow", which increase upon aging [21] or in prodromal phases of neurodegenerative diseases [17].