The aim of this retrospective real-life study was to determine if Finnish patients receiving biological therapy for severe asthma benefit from the treatment due to reduction in exacerbations, OCS dose and courses of OCS and antibiotics in a real-life setting with a broader population than in a randomised controlled trial, and to compare anti-IL5/IL5R therapy results with anti-IgE therapy results in a real-life setting. The gene discussed is IGHE; the disease is asthma.