In this study we evaluated 20 “criteria” and “non-criteria” aPLs targeted at 10 different phospholipids or phospholipid-binding proteins in a cohort of well-defined “highly active serologically” APS patients (i.e. 84% were LAC positive and 55% “triple positive”) aiming to correlate these aPLs with clinical phenotypes of APS. This evidence concerns the gene LCT and autoimmune polyendocrinopathy.