CD40LG and autoimmune polyendocrinopathy: Nevertheless, in the last decade, the significance of aPL persistency and accumulation (i.e. the co-presence of criteria aPLs: anti-cardiolipin (aCL), anti-beta2-glycoprotein1 (aβ2GP1) of the IgG or IgM subtypes and circulating lupus anticoagulant (LAC)) was established, particularly regarding the risk of APS evolvement.