In this study, for the first time to the best of our knowledge, an association between APS-related CNS manifestations and a specific profile of four aPLs namely the co-presence of aPT aPG, aPI and aAN of the IgG isotype was observed, of which, like aPT also aAN and aPI were interrelated with thrombosis [34]. The gene discussed is LYPLA2P1; the disease is autoimmune polyendocrinopathy.