Notably, the presence of aPLs was highly associated with venous thrombosis in general, namely while comparing APS patients to our control groups, 72/77 patients with venous thrombosis were sero-positive for at least 1 aPL (either IgG or IgM) whereas only 7/40 healthy control or 16/58 healthy and sepsis control were positive (p < 0.001 for both comparisons respectively). This evidence concerns the gene CD40LG and Venous thrombosis.