On the other hand, in breast cancer, ESRP1/circANKS1B/miR-148a/ 152-3p/USF1 regulatory circuit contributes to breast cancer invasion and metastasis and induce epithelial to mesenchymal transition through activating the TGF-β1 signaling pathway, thereby, facilitating the development of new treatment strategy against the metastasis of breast cancer [67]. The gene discussed is ESRP1; the disease is breast carcinoma.