One recent study revealed that circular RNA circ-0020397 was upregulated in colorectal cancer, circ-0020397 through circ-0020397 ↑-miR-138- ↓ PD-L1 ↑ to bind PD-1, inhibit T cell proliferation and activation, and induce T cell apoptosis, ultimately resulting in tumor immune escape [57]. This evidence concerns the gene CD274 and neoplasm.