In recent years, drug precise treatments targeting proteins encoding by EGFR, ALK, KRAS, mTOR, ErbB2 and PI3K, and anti-tumor immunity immune check point blockade, like PD-1, PD-L1 and CTLA4 inhibitors, emerge as promising treatments for human malignancies especially a more profound antitumor effect in patients with advanced lung carcinoma [2, 3]. The gene discussed is CD274; the disease is neoplasm.