NES and breast cancer: Pooled results revealed that increased nestin expression in patients with breast cancer predicted worse BCSS in both subgroups (Direct data group: pooled HR = 2.02, 95% CI [1.68, 2.43], P = 0.01, I2 = 0%; Calculated data group: pooled HR = 2.48, 95% CI [1.75, 3.52], P = 0.01, I2 = 0%) (Fig. 2c).