Genes and AS events enrolled in the comprehensive prognostic signature included RHOT1 (ES) [33], SH3KBP1 (AP) [34], AGTRAP (AA) [35], PACS2 (AP) [36], RBPMS (AT) [37], B3GNTL1 (AP) [38], MOBP (AT), NPHP3 (ES), ABCC5 (RI) [39], FKTN (ES) and FKBP8 (AA) [40], many of which are known to play important roles in cancer biology. The gene discussed is SH3KBP1; the disease is cancer.