We also investigated another GC cohort from TCGA (Stomach adenocarcinoma (TCGA, Firehose Legacy), n = 478; http://www.cbioportal.org)16,17 and found that the samples from patients with copy number gain and amplification of the TGM2 gene determined by the GISTIC algorithm exhibited higher mRNA expression levels of TGM2 than those from patients with a diploid TGM2 gene (Fig. S1a, b). Here, TGM2 is linked to gastric adenocarcinoma.