mTOR inhibitors have also been used to modulate glycolysis,140 although their use to mediate tumor interaction with microenvironmental glucose is complicated by the fact that these inhibitors have pleiotropic effects on numerous immune cells and vasculature.151 mTOR’s role in regulating CD8+ T cell differentiation and function, as well as the impact of inhibition on these cells, is an active area of research. Here, CD8A is linked to neoplasm.