CD8A and neoplasm: NY-ESO-1 expression is negatively regulated by DNA methylation and positively regulated by histone acetylation.69–71 Demethylating agents increase NY-ESO-1 expression in tumor cells and induce CD8+ cell immune responses in preclinical models.72 Other antigens, such as MAGE-A1 and endogenenous retroviruses, may also be susceptible to modulation by DNA methyltransferase inhibitors.73