HMGB1 bound to TIM3 on tumor-associated DCs to suppress the recruitment of released nucleic acid from dying tumor cells to the endosome of DC, thus inhibiting nucleic acid-induced innate immune response.86 Furthermore, TIM3 acts on efferocytosis-recognized apoptotic cells via direct PS binding to regulate efferocytosis in DCs. The gene discussed is HMGB1; the disease is neoplasm.