Altered NEAT1 expression has been reported in all major neurodegenerative and psychiatric diseases, including frontotemporal dementia (FTD), Alzheimer’s, Huntington’s and Parkinson’s diseases, amyotrophic lateral sclerosis (ALS), epilepsy, traumatic brain injury and schizophrenia (reviewed in the ref. 15). Here, NEAT1 is linked to amyotrophic lateral sclerosis.