XPO1 and Hepatic fibrosis: Taken together, all these results indicated that miR-451 combined with miR-185 could synergistically attenuate liver fibrosis partly via co-targeting EphB2, and the mechanism of synergy between these two miRNAs is associated with the contributory role of miR-451 in the post-transcriptional regulation of miR-185 maturation by targeting XPO-1.