After an extensive literature review and bioinformatic analysis using available miRNA target-prediction tools online, such as miRbase, miRanda and miRTarBase, we hypothesized that the aberrantly expressed EphB2 might correlate with two liver disease-related miRNAs including miR-451 and miR-185 to drive fibrogenesis. The gene discussed is EPHB2; the disease is liver disorder.