These results were further confirmed in nude mice orthotopic liver cancer xenograft models constructed using HCCLM3 control cells, HCCLM3 lncRNA-SOX2OT-overexpressing cells, HCCLM3 miR-122-5p-overexpressing cells, and HCCLM3 simultaneous lncRNA-SOX2OT- and miR-122-5p-overexpressing cells. This evidence concerns the gene SOX2-OT and liver cancer.