BCAT2 and familial pancreatic carcinoma: Pancreatic ductal adenocarcinoma has a poor prognosis, and is projected to be the second leading cause of cancer death by 2030.34 Abnormal branched-chain amino acid metabolism occurs at the early stage of pancreatic cancer.7 Our study showed that BCAA deprivation induces BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth.