Pancreatic ductal adenocarcinoma has a poor prognosis, and is projected to be the second leading cause of cancer death by 2030.34 Abnormal branched-chain amino acid metabolism occurs at the early stage of pancreatic cancer.7 Our study showed that BCAA deprivation induces BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth. This evidence concerns the gene ARID4B and cancer.