SOAT1 and COVID-19: The defensive role of JAK/STAT pathway is corroborated by evidence demonstrating that the majority of virus have developed escaping strategies, such as the production of viral-encoded factors blocking this pathway, which are recognized as crucial determinants of virulence.87 Therefore, inhibition of JAK/STAT signaling is likely to produce an impairment of IFN-related antiviral response, exacerbating SARS-CoV-2 infection.